Founded in Charleston, South Carolina in 1922 and federated in 1932, The Garden Club of Charleston is one of the oldest and largest garden clubs in America. For 85 years, members have offered tours of private houses and gardens in historic downtown Charleston to fund numerous projects for the benefit of the local community.

The Garden Club of Charleston, Inc. has a long history of civic and beautification projects throughout the Holy City. Highlights of these projects include: 

• 1922-Planted the grounds of the Charleston Library Society at 164 King Street.
• 1930- Executed the landscape design by Loutrel Briggs for the Gateway Walk to help celebrate the 250th anniversary of Charles Towne
• 1954- Erected a marker at the site of Andre Michaux Botanical Garden established north of Charleston in the 18th century; the marker was replaced in 1966.
• 1961- Members planted the Fragrance Garden for the Blind on Pitt Street, and provided Braille markers for the plants.
• 1983- Provided funds to restore the Temple Gate at the Joseph Manigault House a historic property managed by The Charleston Museum
• 1997- Started a therapeutic gardening program for patients at the Medical University of South Carolina Institute of Psychiatry. 
• 2008- Created and funded the first-ever college-level scholarship awarded to a local student in the Horticulture Program at Trident Technical College.
• 2018- The Garden Club of Charleston, Inc. moved and rededicated the Andre Michaux Botanical Garden marker to the Charleston International Airport.
• 2019-  Created The Garden Club of Charleston Scholarship Committee and Fund.
• 2020-  During the global Covid-19 pandemic The Garden Club of Charleston, Inc., conducted their board meetings and general meetings via Zoom, while continuing to fulfill their mission of caring for eight historic gardens, providing scholarships, and many other community activities.
• 2021- Provided opportunities for members to safely gather and for members and community to honor and celebrate our Centennial Anniversary as we emerged from the Covid-19 pandemic.